Prof. Han Jiahuai and his team’s article, “RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice”, was published inCell Host & Microbeon 11 February 2015.

Their major findings include:

1. RIP3-mediated necroptosis plays a vital role in restricting HSV-1 propagation in mice.

2. In mice, HSV-1 ICP6 binds RIP1/3 and promotes their interaction, triggering necroptosis.

3. HSV-1 ICP6 initiates necroptosis in mouse cells but inhibits necroptosis in human cells.

4. Virus-host RHIM interactions can be either pro-necroptotic or anti-necroptotic.

Prof. Han’s team is composed of the co-first author, Zhe Huang, graduates and colleagues in the School of Life Science, Xiamen University.They areSuqin Wu,Yaoji Liang,Xiaojuan Zhou,Wanze Chen,Lisheng Li,Jianfeng Wu,Qiuyu Zhuang,Chang’an Chen,Jingxian Li,Chuanqi Zhong,Weixiang Xia,Rongbin Zhou, andChunfu Zheng.