With the“Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome”published inNature Medicinein 2013,in which they identify for the first time the role of SNX27 in synaptic function establishes a new molecular mechanism of Down's syndrome pathogenesis,Prof. Huaxi Xu and his group continue their study and publish inCell Reportsin 2014“Sorting Nexin 27 Regulates Aβ Production through Modulating γ-secretase Activity”, in which they establish a molecular mechanism for Aβ dependentpathogenesis in both DS and AD.