With the“Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome”published in Nature Medicine in 2013,in which they identify for the first time the role of SNX27 in synaptic function establishes a new molecular mechanism of Down's syndrome pathogenesis, Prof. Huaxi Xu and his group continue their study and publish in Cell Reports in 2014 “Sorting　Nexin　27　Regulates　Aβ　Production　through Modulating　γ-secretase　Activity”, in which they establish a molecular mechanism for Aβ dependent pathogenesis in both DS and AD.